#6853 KIDNEY ELASTOMETRY, KIDNEY MISMATCH INDEX AND CHRONICITY INDEX: NEW METHODS TO INTERROGATE THE DISEASED KIDNEY
نویسندگان
چکیده
Abstract Background and Aims Standard ultrasound mainly offers information about structural kidney alterations which may provide dates regarding the mass of filtrating (e.g. nephron number), or obstructive alterations. Furthermore, parenchymal Doppler resistance index, is highly correlated to plasma creatinine levels. However, in conditions isolated proteinuria with normal function these two classical methods do not reveal any alteration. We have hypothesized that stiffness a mismatch between levels indices offer additional features help nephrologist classification diseases. Method In this respect, we performed transversal study on 468 patients available index both spleen, clinical variables (including hemoglobin, creatinine, cholesterol, proteinuria, hypertension, diabetes) shearwave elastometry, gives an estimate parenchimal stiffness. order identify renal introduced (KMI) derived from ratio chronic patients, argued acute settings (and hence index) are altered whereas size normal: therefore over was tested as quantitative marker chronicity. Results confirm strong correlation (Pearson coeff. 0.318, p<0.01). Interestingly, also significantly dependent age cholesterol using multiple regression model, after adjusting for On contrary, spleen did correlate eGFR, it Overall, could be predicted by (longitudinal diameter, LD) (RI) following formula: = 1.8 -0.175*LD + 2.601* RI Conversely, sharewave stifness only 0.497, p 0.008) but creatinine.Finally, (resistance dissociated levels) does seems particular subsets abnormal microcircle dynamics despite filtration rate, should future studies prognostic factor. Conclusion conclusion, elastometry prove sources valuable informations can gathered allow identification diseased kidneys even presence architecture index.
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2023
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfad063c_6853